Sir Isaac Newton (1643–1727) was an English polymath known for his significant contributions to various fields, including mathematics, physics, astronomy, and alchemy. He played a crucial role in the Scientific Revolution and the Enlightenment, with his most renowned work being "Philosophiæ Naturalis Principia Mathematica," which established classical mechanics. Newton made groundbreaking contributions to optics and is credited with formulating infinitesimal calculus, laying the foundation for modern science. His formulation of the laws of motion and universal gravitation, as well as his work on planetary motion and the nature of light, revolutionized the scientific understanding of the universe. Beyond his scientific pursuits, Newton also engaged in mathematics, biblical chronology, and alchemy. His political and personal affiliations led to his knighthood and service as a Member of Parliament, as well as roles at the Royal Mint and the Royal Society. Newton's exceptional intellect and diverse contributions have left an indelible mark on the scientific and intellectual landscape of the modern world.

Isaac Asimov (January 2, 1920 – April 6, 1992) was an American writer and biochemistry professor at Boston University. As one of the "Big Three" science fiction writers, alongside Robert A. Heinlein and Arthur C. Clarke, he left an indelible mark on the genre. With over 500 books to his name, Asimov's achievements include hard science fiction, mysteries, fantasy, popular science, and non-fiction. He is best known for the Foundation series, which won the Hugo Award for "Best All-Time Series" in 1966. His other notable works include the Galactic Empire series, the Robot series, and over 380 short stories. Asimov's influence extended to his pseudonym, Paul French, under which he wrote the Lucky Starr series. Furthermore, he contributed immensely to popular science with his books on various subjects, from physics to literary criticism. Asimov's legacy lives on through numerous honors, including the asteroid (5020) Asimov, a crater on Mars, and the Honda humanoid robot ASIMO. His impact on literature and science continues to inspire generations.

Isaac Lee Hayes Jr. (August 20, 1942 – August 10, 2008) was a multi-talented American singer, songwriter, composer, and actor. He played a pivotal role in shaping the Southern soul music scene, collaborating with David Porter as a songwriter and session musician at Stax Records in the 1960s. Their partnership produced numerous hits for the duo Sam & Dave, Carla Thomas, and others, earning them induction into the Songwriters Hall of Fame in 2005. Hayes made significant contributions to popular music with his soul albums like Hot Buttered Soul and Black Moses. In addition to his musical career, he ventured into film composition and received critical acclaim for his work on the soundtrack of Shaft, for which he won an Academy Award and two Grammy Awards in 1972. His impact on the music industry was recognized when he was honored as a BMI Icon at the 2003 BMI Urban Awards. Hayes's diverse talents extended to acting, and he appeared in several notable films and television series, including the animated show South Park. His talent and influence in the industry were further underscored by his three Grammy Awards and his humanitarian work, for which he was crowned honorary king of the Ada region of Ghana in 1992. From his early beginnings in Tennessee to his enduring legacy in music and entertainment, Isaac Hayes left an indelible mark on the industry, with his songs continuing to resonate through more than 12 million performances as of

Isaac "Bougie" Herzog, born on 22 September 1960, is the 11th president of Israel, assuming office in 2021. Notably, he is the first president born in Israel after its Declaration of Independence. With a legal background, Herzog previously served as Government Secretary from 1999 to 2001 and was a member of the Knesset from 2003 to 2018. During 2005-2011, he held various ministerial positions, including Minister of Welfare and Social Services. Herzog also chaired the Labor Party and the Zionist Union alliance from 2013 to 2017 and was the Leader of the Opposition from 2013 to 2018. Additionally, he was the Labor Party's candidate for prime minister during the 2015 Israeli legislative election. In 2021, Herzog was elected as the president, becoming the first son of an Israeli president to achieve this honor. Born in Tel Aviv to Major-General Chaim Herzog and Aura Ambache, Herzog's family heritage includes Eastern European Jewish descent. His academic journey took him to Cornell University and New York University, followed by law studies at Tel Aviv University. After serving in the Israel Defense Forces, he worked at a law firm founded by his father. Throughout his political career, Herzog has been involved in various government and opposition roles, emphasizing security and the resolution of the Israeli–Palestinian conflict.

Isaac Edward Slade, born on May 26, 1981, is renowned as an American singer, musician, and former lead vocalist of the Colorado-based rock band, The Fray. Slade's musical journey began at a young age, with an early love for singing and piano, which later led to his songwriting and guitar playing skills. His career took off when he co-founded The Fray, which gained local acclaim with the release of their Movement EP and Reason EP. The band's breakthrough came with the song "Over My Head (Cable Car)", which became a massive hit on Denver radio. After parting ways with The Fray in March 2022, Slade transitioned into running a record store on Vashon Island, Washington. His musical influences include Bush, Nine Inch Nails, Queen, and others. Beyond his musical endeavors, Slade is also known for his philanthropic efforts, such as performing on the 2010 charity single "We Are the World" and participating in the Colorado Flood Benefit Concert. In the realm of politics, Slade identifies as a centrist and has supported independent candidates.