Phyre is a gender-neutral name of American origin, meaning "fire." It is associated with the element of fire, symbolizing passion, energy, and transformation. The name Phyre is also linked to the Phyre and Phyre2 protein structure prediction servers, which utilize advanced techniques to predict the three-dimensional structure of protein sequences. These servers employ homology modeling, aligning protein sequences to known structures to generate accurate models. Phyre2, an enhanced version of the original Phyre server, offers additional functions such as batch processing, one-to-one threading, and transmembrane topology prediction. The applications of Phyre and Phyre2 include protein structure and function prediction, domain analysis, and evolutionary classification of proteins. The name Phyre reflects strength, innovation, and the pursuit of knowledge, making it an intriguing choice for individuals seeking a name with a fiery and dynamic connotation.